Webinar – AR-V7 Key in Tx of mCRPC

27th June

Webinar “AR-V7 Key in Tx of mCRPC” by Andrew Armstrong, MD, presented at ASCO

> Watch the webinar

Using TATAA GrandPerformance assays, AR-V7 status can be tested with single cell sensitivity.

AH Seminar Day

25th June

AH Seminar Day

Copenhagen on Sept. 6

Join Mikael Kubista’s presentation of Two-Tailed PCR!

National and international key opinion leaders will present exciting new data from cutting-edge  research with a variety of scientific presentations. You will also have the opportunity to network  with colleagues throughout the day.

Biomarkörer i utandningsluft

19th June

TATAA inleder samarbete med PExA kring analys av biomarkörer i utandningsluft

PExA AB (”PExA”) och TATAA Biocenter har inlett ett samarbete med målsättning att utveckla analysmetoder som möjliggör att nya typer av biomarkörer kan upptäckas med PExAs teknologi.

I samarbetet kombineras PExAs unika teknologiplattform med TATAA Biocenters välrenommerade expertis inom biokemisk analys av biologiska prover. Projektet avser att utveckla nya och för PExA speciellt anpassade metoder för analys av en ny typ av biomarkörer som av medicinforskare anses ha stor potential.

> Read more

New metabolic checkpoint described

14th June

Researchers including TATAA describe new metabolic checkpoint in Nature Communications.

Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints

TATAA ska utveckla ultrakänsliga analys

14th June

Ultrakänsliga analyser för bättre hälsa och kriminalteknik (ULTRA-UDI)

Konsortium innefattande TATAA har erhållit finansiering av Vinnova för att utveckla ultrakänsliga analys, däribland TATAAs Two-tailed PCR teknik, som erbjuder överlägsen känslighet och specificitet.

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Small RNA in bodily fluids

4th June

Small RNA in bodily fluids

> Research article: Diversity and signature of small RNA in different bodily fluids using next generation sequencing

Background:

Small RNAs are critical components in regulating various cellular pathways. These molecules may be tissue-associated or circulating in bodily fluids and have been shown to associate with different tumors. Next generation sequencing (NGS) on small RNAs is a powerful tool for profiling and discovery of microRNAs (miRNAs).

Results:

In this study, we isolated total RNA from various bodily fluids: blood, leukocytes, serum, plasma, saliva, cell-free saliva, urine and cell-free urine. Next, we used Illumina’s NGS platform and intensive bioinformatics analysis to investigate the distribution and signature of small RNAs in the various fluids. Successful NGS was accomplished despite the variations in RNA concentrations among the different fluids. Among the fluids studied, blood and plasma were found to be the most promising fluids for small RNA profiling as well as novel miRNA prediction. Saliva and urine yielded lower numbers of identifiable molecules and therefore were less reliable in small RNA profiling and less useful in predicting novel molecules. In addition, all fluids shared many molecules, including 139 miRNAs, the most abundant tRNAs, and the most abundant piwi-interacting RNAs (piRNAs). Fluids of similar origin (blood, urine or saliva) displayed closer clustering, while each fluid still retains its own characteristic signature based on its unique molecules and its levels of the common molecules. Donor urine samples showed sex-dependent differential clustering, which may prove useful for future studies.

Conclusions:

This study shows the successful clustering and unique signatures of bodily fluids based on their miRNA, tRNA and piRNA content. With this information, cohorts may be differentiated based on multiple molecules from each small RNA class by a multidimensional assessment of the overall molecular signature.

Molecular microbiological identification and typing

1st June

Want to learn about Molecular microbiological identification and typing?

Join our 2-days course on the 26-27th of September, in collaboration with RISE!

The course provides an overview of techniques and gives advice on how to interpret the complex data that are generated. The course focuses on quantitative PCR, whole genome sequencing and metagenomics.

> Course description

> Registration